DAR No 4: Linaclotide. Constella® in the symptomatic management of irritable bowel syndrome with constipation

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The indication was granted...so what?

Although authorized for irritable bowel syndrome with constipation it offers only symptomatic relief.
In the best of cases, one in five patients can benefit from treatment.
On the other hand, one in five patients can suffer from diarrhea as a secondary effect which can last for more than 28 days in half the cases.
There are no available studies evaluating linaclotide versus other recommended comparators (laxatives and spasmolytics).

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